If one has the unfortunate circumstance of possessing only a single functioning kidney, it is crucial to understand and prioritize certain lifestyle choices in order to ensure optimal renal health. Firstly, abstaining from excessive alcohol consumption is imperative as it places undue stress on the remaining kidney, hindering its ability to effectively filter toxins. Similarly, avoiding medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) can safeguard the singular kidney from potential harm and maintain its functionality. Since hypertension poses a significant threat to renal function, individuals with a solitary kidney should diligently regulate their blood pressure through methods such as regular exercise, a well-balanced diet low in sodium, and minimal stress levels. Moreover, maintaining hydrated adequately is paramount as dehydration can result in decreased blood flow to the kidneys and potential damage. Finally, adhering conscientiously to follow-up appointments with healthcare professionals for routine check-ups and monitoring will allow early detection of any complications or changes in kidney function. Consequently, consistent avoidance of alcohol abuse, NSAID usage, hypertension risks mitigation, hydration maintenance, and medical vigilance are fundamental aspects in preserving one’s sole functioning kidney’s wellbeing.