Varicose veins, influenced by hormonal changes, is a common condition among individuals, particularly women, during different stages of their lives. Hormonal fluctuations have a direct impact on the structure and elasticity of blood vessels, resulting in the swollen and twisted appearance characteristic of varicose veins. During pregnancy, for example, increased levels of progesterone cause blood vessels to relax and widen, making them more prone to becoming varicose. Similarly, menopause brings about decreased levels of estrogen that negatively affect vein health. Furthermore, the use of hormone replacement therapy (HRT) has been linked to an increased risk of developing varicose veins. While hormonal influence plays a significant role in the formation of varicose veins, other factors such as age, genetics, obesity, and prolonged standing or sitting should also be taken into consideration when managing this condition professionally. Thus, understanding the intertwined relationship between hormones and varicose veins is crucial for healthcare professionals to provide appropriate treatment options and preventive measures tailored to individual patients’ needs.